MERS-CoV in Dromedary Camels: Sequence-Based Comparison of Antigenicity and Pathogenicity of Structural and Non-Structural Proteins

The goal of this researcher was to map the camel MERS-CoV structural and non-structural proteins track changes in antigenicity pathogenicity from 2013 2018. This is critical for developing effective diagnostic control methods. Therefore, sequences such as Spike (S), Membrane (M), Nucleocapsid (N) Envelope (E) nonstructural proteins, comprising polyprotein-ab (polyab) Open reading frame-3 (ORF3) were retrieved. amino acid each these analysed estimate their antigenic pathogenic properties profiles showed variations minimum, maximum, range, average proteins’ maximum score declining examined time frame. In 2013, 0.86, by 2018, it had dropped 0.6. resulted a greater range with onset 0.56, which eventually decreased 0.22 net effect on mean value revealed that gradually. Between decreased. Non-structural other hand, greatest alterations, 0.52 0.42 representing loss 19.2 per cent score. contrast, protein 0.55 0.53 i.e. lost only 3.6% its Given ORF3 nonantigenic, therefore, all attributed polyab protein. Pathogenicity has 0.81 0.78 Further studies are required virus-host cell interaction level.